Development of a Photo-crosslinkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium Falciparum

Diaminoquinazolines represent a privileged scaffold for antimalarial discovery, including use as putative Plasmodium histone lysine methyltransferase inhibitors. Despite this, robust evidence for their molecular targets is lacking. Here we report the design and development of a small-molecule photo-...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Lubin, Alexandra, Rueda-Zubiaurre, Ainoa, Matthews, Holly, Baumann, Hella, Fisher, Fabio R., Morales-Sanfrutos, Julia, Hadavizadeh, Kate S., Nardella, Flore, Tate, Edward W., Baum, Jake, Schef, Artur, Fuchter, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220801/
https://ncbi.nlm.nih.gov/pubmed/29377668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00228
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