Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

Calcium (Ca(2+))-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca(2+)-influx. The principal components involved in these processes are the vesicular fusion machinery (SNARE pro...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Ramakrishnan, Sathish, Bera, Manindra, Coleman, Jeff, Rothman, James E, Krishnakumar, Shyam S
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Structural Biology and Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220375/
https://ncbi.nlm.nih.gov/pubmed/32401194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54506
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