Multi-Omics analysis identifies MGA as a negative regulator of the MYC pathway in lung adenocarcinoma

Genomic analysis of lung adenocarcinomas has revealed that the MGA gene, which encodes a heterodimeric partner of the MYC-interacting protein MAX, is significantly mutated or deleted in lung adenocarcinomas. Most of the mutations are loss-of-function for MGA, suggesting that MGA may act as a tumor s...

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Publicado en:Mol Cancer Res
Autores principales: Llabata, Paula, Mitsuishi, Yoichiro, Choi, Peter S., Cai, Diana, Francis, Joshua M., Torres-Diz, Manuel, Udeshi, Namrata D., Golomb, Lior, Wu, Zhong, Zhou, Jin, Svinkina, Tanya, Aguilera-Jimenez, Estrella, Liu, Yanli, Carr, Steven A., Sanchez-Cespedes, Montse, Meyerson, Matthew, Zhang, Xiaoyang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219472/
https://ncbi.nlm.nih.gov/pubmed/31862696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0657
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