The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4–positive T cells that are PD-1–negative

Classic Hodgkin lymphoma (cHL) is a tumor composed of rare, atypical, germinal center–derived B cells (Hodgkin Reed-Sternberg [HRS] cells) embedded within a robust but ineffective inflammatory milieu. The cHL tumor microenvironment (TME) is compartmentalized into “niches” rich in programmed cell dea...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Patel, Sanjay S., Weirather, Jason L., Lipschitz, Mikel, Lako, Ana, Chen, Pei-Hsuan, Griffin, Gabriel K., Armand, Philippe, Shipp, Margaret A., Rodig, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218752/
https://ncbi.nlm.nih.gov/pubmed/31697809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002206
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