Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins

Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction. To fill this therapeutic gap, we examined a potential role for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)...

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Udgivet i:Front Pharmacol
Main Authors: Lu, Robin A., Zeki, Amir A., Ram-Mohan, Sumati, Nguyen, Nhan, Bai, Yan, Chmiel, Kenneth, Pecic, Stevan, Ai, Xingbin, Krishnan, Ramaswamy, Ghosh, Chandra C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218099/
https://ncbi.nlm.nih.gov/pubmed/32435188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00469
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