Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling

One-carbon metabolism fuels the high demand of cancer cells for nucleotides and other building blocks needed for increased proliferation. Although inhibitors of this pathway are widely used to treat many cancers, their global impact on anabolic and catabolic processes remains unclear. Using a combin...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Papadopoli, David J., Ma, Eric H., Roy, Dominic, Russo, Mariana, Bridon, Gaëlle, Avizonis, Daina, Jones, Russell G., St-Pierre, Julie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217946/
https://ncbi.nlm.nih.gov/pubmed/32398698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64460-z
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires