Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis

BACKGROUND: Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the interaction between cancer cells and stromal pancreatic stellate cells (PSCs). This study assessed the effect of HGF/c-MET inh...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Xu, Zhihong, Pang, Tony C. Y., Liu, Adele C., Pothula, Srinivasa P., Mekapogu, Alpha Raj, Perera, Chamini J., Murakami, Takashi, Goldstein, David, Pirola, Romano C., Wilson, Jeremy S., Apte, Minoti V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217847/
https://ncbi.nlm.nih.gov/pubmed/32203220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0782-1
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