Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer

BACKGROUND: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is the HGF–c-MET pathway. METHODS: Effects of HGF inhibition (using a neutralising...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Pothula, Srinivasa P, Xu, Zhihong, Goldstein, David, Biankin, Andrew V, Pirola, Romano C, Wilson, Jeremy S, Apte, Minoti V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742591/
https://ncbi.nlm.nih.gov/pubmed/26766740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.478
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