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Suppression of Iron Mobilization from Lysosomes to Mitochondria Attenuates Liver Injury after Acetaminophen Overdose In Vivo in Mice: Protection by Minocycline
Acetaminophen (APAP) overdose causes hepatotoxicity involving mitochondrial dysfunction. Previous studies showed that translocation of Fe(2+) from lysosomes into mitochondria by the mitochondrial Ca(2+) uniporter (MCU) promotes the mitochondrial permeability transition (MPT) after APAP. Here, our Ai...
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| Publicat a: | Toxicol Appl Pharmacol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7217634/ https://ncbi.nlm.nih.gov/pubmed/32109512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.114930 |
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