Translocation of Iron from Lysosomes to Mitochondria during Acetaminophen-Induced Hepatocellular Injury: Protection by Starch-Desferal and Minocycline

Acetaminophen (APAP) overdose causes hepatotoxicity involving mitochondrial dysfunction and the mitochondrial permeability transition (MPT). Iron is a critical catalyst for ROS formation, and reactive oxygen species (ROS) play an important role in APAP-induced hepatotoxicity. Previous studies show t...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Hu, Jiangting, Kholmukhamedov, Andaleb, Lindsey, Christopher C., Beeson, Craig C., Jaeschke, Hartmut, Lemasters, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996678/
https://ncbi.nlm.nih.gov/pubmed/27345134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.06.024
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