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Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms
BACKGROUND: The serine/threonine kinases MST1 and MST2 are core components of the Hippo pathway, which has been found to be critically involved in embryonic kidney development. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the pathway’s main effectors....
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| Udgivet i: | J Am Soc Nephrol |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Nephrology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7217407/ https://ncbi.nlm.nih.gov/pubmed/32253273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019101052 |
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