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Real‐Time BODIPY‐Binding Assay To Screen Inhibitors of the Early Oligomerization Process of Aβ1–42 Peptide

Misfolding and aggregation of amyloid β1–42 peptide (Aβ1–42) play a central role in the pathogenesis of Alzheimer's disease (AD). Targeting the highly cytotoxic oligomeric species formed during the early stages of the aggregation process represents a promising therapeutic strategy to reduce the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chembiochem
Prif Awduron: Tonali, Nicolo, Dodero, Veronica I., Kaffy, Julia, Hericks, Loreen, Ongeri, Sandrine, Sewald, Norbert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217026/
https://ncbi.nlm.nih.gov/pubmed/31702868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900652
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