Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction

Abstract The accumulation of intracellular aggregates of Tau protein is one main hallmark of Alzheimer’s disease (AD) and is the consequence of Tau conformational changes, increased phosphorylation, and self-association to form fibrillar aggregates. This pathological process prevents the physiologic...

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Auteurs principaux:	Davide Di Lorenzo, Nicolo Bisi, Julia Kaffy, Lisa Marie Ramirez, Markus Zweckstetter, Olivier Lequin, Irene Garfagnini, Jinghui Luo, Yvonne Hannappel, Inga Ennen, Veronica Dodero, Norbert Sewald, Maria Luisa Gelmi, Nicolo Tonali, Roland Brandt, Sandrine Ongeri
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-10-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-025-63824-1
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