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Tau induces cooperative Taxol binding to microtubules
Taxol and tau are two ligands that stabilize the microtubule (MT) lattice. Taxol is an anti-mitotic drug that binds β tubulin in the MT interior. Tau is a MT-associated protein that binds both α and β tubulin on the MT exterior. Both Taxol and tau reduce MT dynamics and promote tubulin polymerizatio...
Sparad:
| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2004
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516494/ https://ncbi.nlm.nih.gov/pubmed/15326286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402928101 |
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