Tau induces cooperative Taxol binding to microtubules
Taxol and tau are two ligands that stabilize the microtubule (MT) lattice. Taxol is an anti-mitotic drug that binds β tubulin in the MT interior. Tau is a MT-associated protein that binds both α and β tubulin on the MT exterior. Both Taxol and tau reduce MT dynamics and promote tubulin polymerizatio...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516494/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15326286/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402928101 |
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