The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands

Pentapeptides having the sequence R-HN-Ala-Val-X-Val-Leu-OMe, where the central residue X is L-serine, L-threonine, (2S,3R)-L-CF(3)-threonine and (2S,3S)-L-CF(3)-threonine were prepared. The capacity of (2S,3S)- and (2S,3R)-CF(3)-threonine analogues to stabilize an extended structure when introduced...

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Detalles Bibliográficos
Publicado en:Beilstein J Org Chem
Main Authors: Xu, Yaochun, Correia, Isabelle, Ha-Duong, Tap, Kihal, Nadjib, Soulier, Jean-Louis, Kaffy, Julia, Crousse, Benoît, Lequin, Olivier, Ongeri, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado: Beilstein-Institut 2017
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Full Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753055/
https://ncbi.nlm.nih.gov/pubmed/29564012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.276
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