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Translational regulation of periplasmic folding assistants and proteases as a valuable strategy to improve production of translocated recombinant proteins in Escherichia coli

BACKGROUND: Advantages of translocation of recombinant proteins to the periplasm in Escherichia coli include simplified downstream processing, and improved folding and in vivo activity of the target protein. There are, however, problems encountered in the periplasmic production that can be associate...

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Detalhes bibliográficos
Publicado no:BMC Biotechnol
Main Authors: Gawin, Agnieszka, Ertesvåg, Helga, Hansen, Sine Alise Hartvigsen, Malmo, Jostein, Brautaset, Trygve
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216727/
https://ncbi.nlm.nih.gov/pubmed/32393331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-020-00615-0
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