Translational regulation of periplasmic folding assistants and proteases as a valuable strategy to improve production of translocated recombinant proteins in Escherichia coli

BACKGROUND: Advantages of translocation of recombinant proteins to the periplasm in Escherichia coli include simplified downstream processing, and improved folding and in vivo activity of the target protein. There are, however, problems encountered in the periplasmic production that can be associate...

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Veröffentlicht in:BMC Biotechnol
Hauptverfasser: Gawin, Agnieszka, Ertesvåg, Helga, Hansen, Sine Alise Hartvigsen, Malmo, Jostein, Brautaset, Trygve
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216727/
https://ncbi.nlm.nih.gov/pubmed/32393331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-020-00615-0
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