Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction

Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clinical problem that leads to a reduction in mobility, increased risk of pathologic fracture, severe bone pain, and other skeletal-related events. The transcription factor Gli2 drives expression of parat...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Vanderburgh, Joseph, Hill, Jordan L., Gupta, Mukesh K., Kwakwa, Kristin A., Wang, Sean K., Moyer, Kathleen, Bedingfield, Sean K., Merkel, Alyssa R., d’Arcy, Richard, Guelcher, Scott A., Rhoades, Julie A., Duvall, Craig L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216559/
https://ncbi.nlm.nih.gov/pubmed/31894963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b04571
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