Systemic Delivery of a Gli Inhibitor via Polymeric Nanocarriers Inhibits Tumor-Induced Bone Disease

Solid tumors frequently metastasize to bone and induce bone destruction leading to severe pain, fractures, and other skeletal-related events (SREs). Osteoclast inhibitors such as bisphosphonates delay SREs but do not prevent skeletal complications or improve overall survival. Because bisphosphonates...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Vanderburgh, Joseph P., Kwakwa, Kristin A., Werfel, Thomas A., Merkel, Alyssa R., Gupta, Mukesh K., Johnson, Rachelle W., Guelcher, Scott A., Duvall, Craig L., Rhoades (Sterling), Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007697/
https://ncbi.nlm.nih.gov/pubmed/31494183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.08.038
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