Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis

BACKGROUND: A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity. EOC spheroids are subjected to bioenergetic stress, thereby activating AMP-activated protein kina...

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Dettagli Bibliografici
Pubblicato in:J Ovarian Res
Autori principali: Laski, Jeremi, Singha, Bipradeb, Wang, Xu, Valdés, Yudith Ramos, Collins, Olga, Shepherd, Trevor G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216359/
https://ncbi.nlm.nih.gov/pubmed/32393385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-020-00660-5
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