Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress

Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cells may be an important source of oxidative stress a...

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Detaylı Bibliyografya
Yayımlandı:J Mol Cell Cardiol
Asıl Yazarlar: Morgan, R. Garrett, Walker, Ashley E., Trott, Daniel W., Machin, Daniel R., Henson, Grant D., Reihl, Kelly D., Cawthon, Richard M., Denchi, Eros L., Liu, Yu, Bloom, Samuel I., Phuong, Tam T., Richardson, Russell S., Lesniewski, Lisa A., Donato, Anthony J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216296/
https://ncbi.nlm.nih.gov/pubmed/30502348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.11.014
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