Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

Arterial telomere dysfunction may contribute to chronic arterial inflammation by inducing cellular senescence and subsequent senescence-associated inflammation. Although telomere shortening has been associated with arterial aging in humans, age-related telomere uncapping has not been described in no...

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Bibliografiska uppgifter
Huvudupphovsmän: Morgan, Richard G., Ives, Stephen J., Lesniewski, Lisa A., Cawthon, Richard M., Andtbacka, Robert H. I., Noyes, R. Dirk, Richardson, Russell S., Donato, Anthony J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2013
Ämnen:
Integrative Cardiovascular Physiology and Pathophysiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726958/
https://ncbi.nlm.nih.gov/pubmed/23666675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00197.2013
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