Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress

Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cells may be an important source of oxidative stress a...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Morgan, R. Garrett, Walker, Ashley E., Trott, Daniel W., Machin, Daniel R., Henson, Grant D., Reihl, Kelly D., Cawthon, Richard M., Denchi, Eros L., Liu, Yu, Bloom, Samuel I., Phuong, Tam T., Richardson, Russell S., Lesniewski, Lisa A., Donato, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216296/
https://ncbi.nlm.nih.gov/pubmed/30502348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.11.014
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