Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

Aldosterone (Aldo), when overproduced, is a cardiotoxic hormone underlying heart failure and hypertension. Aldo exerts damaging effects via the mineralocorticoid receptor (MR) but also activates the antiapoptotic G protein-coupled estrogen receptor (GPER) in the heart. G protein-coupled receptor (GP...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Maning, Jennifer, McCrink, Katie A., Pollard, Celina M., Desimine, Victoria L., Ghandour, Jennifer, Perez, Arianna, Cora, Natalie, Ferraino, Krysten E., Parker, Barbara M., Brill, Ava R., Aukszi, Beatrix, Lymperopoulos, Anastasios
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7215681/
https://ncbi.nlm.nih.gov/pubmed/32326036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21082868
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