Hypoxia, Inflammation and Necrosis as Determinants of Glioblastoma Cancer Stem Cells Progression

Tumor hypoxic microenvironment causes hypoxia inducible factor 1 alpha (HIF-1α) activation and necrosis with alarmins release. Importantly, HIF-1α also controls the expression of alarmin receptors in tumor cells that can bind to and be activated by alarmins. Human tumor tissues possess 1–2% of cance...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Papale, Marco, Buccarelli, Mariachiara, Mollinari, Cristiana, Russo, Matteo A., Pallini, Roberto, Ricci-Vitiani, Lucia, Tafani, Marco
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7215563/
https://ncbi.nlm.nih.gov/pubmed/32290386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21082660
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