Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair

The composition and biological activity of donor cells is largely determined by the exosomes they secrete. In this study, we isolated exosomes from young (Young-Exo) and aged (Age-Exo) mesenchymal stem cells (MSCs) and compared their regeneration activity. Young Exo MSCs were more efficient than Age...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Sun, Ling, Zhu, Wenwu, Zhao, Pengcheng, Zhang, Jian, Lu, Yao, Zhu, Yeqian, Zhao, Wei, Liu, Yaowu, Chen, Qiushi, Zhang, Fengxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214920/
https://ncbi.nlm.nih.gov/pubmed/32432109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00263
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