Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)

BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair. Recurrent mutations in BRCC3 have been reported in myelodysplastic syndromes (MDS) but not in de novo AML. In one of our rece...

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Detaylı Bibliyografya
Yayımlandı:Leukemia
Asıl Yazarlar: Meyer, Tatjana, Jahn, Nikolaus, Lindner, Stefanie, Röhner, Linda, Dolnik, Anna, Weber, Daniela, Scheffold, Annika, Köpff, Simon, Paschka, Peter, Gaidzik, Verena I., Heckl, Dirk, Wiese, Sebastian, Ebert, Benjamin L., Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze, Krönke, Jan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214237/
https://ncbi.nlm.nih.gov/pubmed/31576005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0578-6
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