Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)

BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair. Recurrent mutations in BRCC3 have been reported in myelodysplastic syndromes (MDS) but not in de novo AML. In one of our rece...

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Publicat a:Leukemia
Autors principals: Meyer, Tatjana, Jahn, Nikolaus, Lindner, Stefanie, Röhner, Linda, Dolnik, Anna, Weber, Daniela, Scheffold, Annika, Köpff, Simon, Paschka, Peter, Gaidzik, Verena I., Heckl, Dirk, Wiese, Sebastian, Ebert, Benjamin L., Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze, Krönke, Jan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214237/
https://ncbi.nlm.nih.gov/pubmed/31576005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0578-6
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