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Hormonal suppression of stem cells inhibits symmetric cell division and gastric tumorigenesis

Cancer is believed to arise from stem cells, but mechanisms that limit the acquisition of mutations and tumor development have not been well-defined. We show that a +4 stem cell (SC) in the gastric antrum, marked by expression of Cck2r (a GPCR) and Delta-like ligand 1 (DLL1), is a label-retaining ce...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Stem Cell
Κύριοι συγγραφείς: Chang, Wenju, Wang, Hongshan, Kim, Woosook, Liu, Yang, Deng, Huan, Liu, Haibo, Jiang, Zhengyu, Niu, Zhengchuan, Sheng, Weiwei, Nápoles, Osmel Companioni, Sun, Yihong, Xu, Jianmin, Sepulveda, Antonia, Hayakawa, Yoku, Bass, Adam J., Wang, Timothy C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2020
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214188/
https://ncbi.nlm.nih.gov/pubmed/32142681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.01.020
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