Hypergastrinemia Expands Gastric ECL Cells Through CCK2R(+) Progenitor Cells via ERK Activation

BACKGROUND & AIMS: Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL cells or increased production from progenitors has not been clarified. METH...

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Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Sheng, Weiwei, Malagola, Ermanno, Nienhüser, Henrik, Zhang, Zhengyu, Kim, Woosook, Zamechek, Leah, Sepulveda, Antonia, Hata, Masahiro, Hayakawa, Yoku, Zhao, Chun-Mei, Chen, Duan, Wang, Timothy C.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371950/
https://ncbi.nlm.nih.gov/pubmed/32330731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.04.008
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