PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice

BACKGROUND & AIMS: Immune checkpoint inhibitors have limited efficacy in many tumors. We investigated mechanisms of tumor resistance to inhibitors of programmed cell death 1 (PDCD1, also called PD1) in mice with gastric cancer, and the role of its ligand, PDL1. METHODS: Gastrin-deficient mice we...

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Publicado en:Gastroenterology
Autores principales: Kim, Woosook, Chu, Timothy H., Nienhüser, Henrik, Jiang, Zhengyu, Portillo, Armando Del, Remotti, Helen E., White, Ruth A., Hayakawa, Yoku, Tomita, Hiroyuki, Fox, James G., Drake, Charles G., Wang, Timothy C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878361/
https://ncbi.nlm.nih.gov/pubmed/33129844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.10.036
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