Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

Mammalian cells typically start the cell-cycle entry program by activating cyclin-dependent protein kinase 4/6 (CDK4/6). CDK4/6 activity is clinically relevant as mutations, deletions, and amplifications that increase CDK4/6 activity contribute to the progression of many cancers. However, when CDK4/...

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Publicado en:eLife
Autores principales: Yang, Hee Won, Cappell, Steven D, Jaimovich, Ariel, Liu, Chad, Chung, Mingyu, Daigh, Leighton H, Pack, Lindsey R, Fan, Yilin, Regot, Sergi, Covert, Markus, Meyer, Tobias
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213986/
https://ncbi.nlm.nih.gov/pubmed/32255427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44571
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