Biased Signaling of the G Protein-Coupled Receptor β(2)AR is Governed by Conformational Exchange Kinetics

G protein-coupled receptors (GPCRs) mediate a wide range of human physiological functions by transducing extracellular ligand binding events into intracellular responses. GPCRs can activate parallel, independent signaling pathways mediated by G proteins or β-arrestins. Whereas “balanced” agonists ac...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Lamichhane, Rajan, Liu, Jeffrey J., White, Kate L., Katritch, Vsevolod, Stevens, Raymond C., Wüthrich, Kurt, Millar, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213800/
https://ncbi.nlm.nih.gov/pubmed/31978323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.01.001
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