Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β(2)AR

Binding of extracellular ligands to G protein-coupled receptors (GPCRs) initiates transmembrane signaling by inducing conformational changes on the cytoplasmic receptor surface. Knowledge of this process provides a platform for the development of GPCR-targeting drugs. Here, using a site-specific Cy3...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lamichhane, Rajan, Liu, Jeffrey J., Pljevaljcic, Goran, White, Kate L., van der Schans, Edwin, Katritch, Vsevolod, Stevens, Raymond C., Wüthrich, Kurt, Millar, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655547/
https://ncbi.nlm.nih.gov/pubmed/26578769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519626112
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