THER-11. PEPTIDE-MEDIATED PERMEABILIZATION OF THE BLOOD-BRAIN BARRIER IMPROVES DRUG DELIVERY TO BRAIN METASTASIS

BACKGROUND: Melanoma patients have a high risk of developing brain metastases, which is associated with a poor prognosis. The blood-brain barrier (BBB) inhibits sufficient drug delivery into metastatic lesions. We investigated the ability of a synthetic peptide (K16ApoE) to permeabilize the BBB for...

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Udgivet i:Neurooncol Adv
Main Authors: Aasen, Synnøve Nymark, Espedal, Heidi, Holte, Christopher, Keunen, Olivier, Karlsen, Tine Veronika, Tenstad, Olav, Maherally, Zaynah, Miletic, Hrvoje, Hoang, Tuyen, Eikeland, Anne Vaag, Baghirov, Habib, Olberg, Dag Erlend, Pilkington, Geoffrey J, Sarkar, Gobinda, Jenkins, Robert, Sundstrøm, Terje, Bjerkvig, Rolf, Thorsen, Frits
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213147/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz014.054
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