THER-11. PEPTIDE-MEDIATED PERMEABILIZATION OF THE BLOOD-BRAIN BARRIER IMPROVES DRUG DELIVERY TO BRAIN METASTASIS

BACKGROUND: Melanoma patients have a high risk of developing brain metastases, which is associated with a poor prognosis. The blood-brain barrier (BBB) inhibits sufficient drug delivery into metastatic lesions. We investigated the ability of a synthetic peptide (K16ApoE) to permeabilize the BBB for...

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Publicat a:Neurooncol Adv
Autors principals: Aasen, Synnøve Nymark, Espedal, Heidi, Holte, Christopher, Keunen, Olivier, Karlsen, Tine Veronika, Tenstad, Olav, Maherally, Zaynah, Miletic, Hrvoje, Hoang, Tuyen, Eikeland, Anne Vaag, Baghirov, Habib, Olberg, Dag Erlend, Pilkington, Geoffrey J, Sarkar, Gobinda, Jenkins, Robert, Sundstrøm, Terje, Bjerkvig, Rolf, Thorsen, Frits
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213147/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz014.054
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