THER-11. PEPTIDE-MEDIATED PERMEABILIZATION OF THE BLOOD-BRAIN BARRIER IMPROVES DRUG DELIVERY TO BRAIN METASTASIS

BACKGROUND: Melanoma patients have a high risk of developing brain metastases, which is associated with a poor prognosis. The blood-brain barrier (BBB) inhibits sufficient drug delivery into metastatic lesions. We investigated the ability of a synthetic peptide (K16ApoE) to permeabilize the BBB for...

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Publicado no:Neurooncol Adv
Main Authors: Aasen, Synnøve Nymark, Espedal, Heidi, Holte, Christopher, Keunen, Olivier, Karlsen, Tine Veronika, Tenstad, Olav, Maherally, Zaynah, Miletic, Hrvoje, Hoang, Tuyen, Eikeland, Anne Vaag, Baghirov, Habib, Olberg, Dag Erlend, Pilkington, Geoffrey J, Sarkar, Gobinda, Jenkins, Robert, Sundstrøm, Terje, Bjerkvig, Rolf, Thorsen, Frits
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213147/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz014.054
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