Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

BACKGROUND: Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug–drug interactions. MATERIALS AND METHODS: Given statins have the possibility of combination with lidocaine in the clinic, we established in vit...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Wang, Ying, Ou-yang, Qiu-geng, Huang, Wan-li, Huang, Huan-le, Zhuang, Xin-lei, Lin, Qian-meng, Zeng, Da-li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212776/
https://ncbi.nlm.nih.gov/pubmed/32440099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S241022
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