Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro

Background. Hypercholesterolemia and disruptions of the blood brain barrier (BBB) have been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease (AD). Simvastatin therapy may be of benefit in treating AD; however, its mechanism has not been yet fully understood. Object...

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Detalhes bibliográficos
Main Authors: Jiang, Xijuan, Guo, Maojuan, Su, Jinling, Lu, Bin, Ma, Dongming, Zhang, Ruifeng, Yang, Lin, Wang, Qiang, Ma, Yiwen, Fan, Yingchang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296225/
https://ncbi.nlm.nih.gov/pubmed/22506129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/109324
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