Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors

Glial cell line–derived neurotrophic factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor α1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Jmaeff, Sean, Sidorova, Yulia, Nedev, Hinyu, Saarma, Mart, Saragovi, H. Uri
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212635/
https://ncbi.nlm.nih.gov/pubmed/32245892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011802
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