Gfra1 Underexpression Causes Hirschsprung’s Disease and Associated Enterocolitis in Mice

BACKGROUND & AIMS: RET, the receptor for the glial cell line–derived neurotrophic factor (GDNF) family ligands, is the most frequently mutated gene in congenital aganglionic megacolon or Hirschsprung’s disease (HSCR). The leading cause of mortality in HSCR is HSCR-associated enterocolitis (HAEC)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Mol Gastroenterol Hepatol
Egile Nagusiak: Porokuokka, L. Lauriina, Virtanen, Heikki T., Lindén, Jere, Sidorova, Yulia, Danilova, Tatiana, Lindahl, Maria, Saarma, Mart, Andressoo, Jaan-Olle
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2018
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444303/
https://ncbi.nlm.nih.gov/pubmed/30594740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.12.007
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