Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient(1,2). Despite its widespread use our understanding of t...

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Bibliografiska uppgifter
I publikationen:Nat Metab
Huvudupphovsmän: Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212038/
https://ncbi.nlm.nih.gov/pubmed/32395697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0115-y
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