Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient(1,2). Despite its widespread use our understanding of t...

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Vydáno v:Nat Metab
Hlavní autoři: Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212038/
https://ncbi.nlm.nih.gov/pubmed/32395697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0115-y
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