Llwytho...
Lis1 activates dynein motility by modulating its pairing with dynactin
Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules (MTs). It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility. Here we use single-molecule imaging and optical trapping to show tha...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Cell Biol |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7212015/ https://ncbi.nlm.nih.gov/pubmed/32341547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0501-4 |
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