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Molecular mechanism of dynein-dynactin complex assembly by LIS1

Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It functions as a ~4 MDa complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor. However, how dynein and dynactin recognize diverse adaptors, how they interact with each other during co...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Singh, Kashish, Lau, Clinton K., Manigrasso, Giulia, Gama, José B., Gassmann, Reto, Carter, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2024
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615804/
https://ncbi.nlm.nih.gov/pubmed/38547289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adk8544
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