Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition

Recent clinical trials have revealed that aggressive insulin treatment has a neutral effect on cardiovascular risk in patients with diabetes despite improved glycemic control, which may suggest confounding direct effects of insulin on the human vasculature. We studied 580 patients with coronary athe...

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Publicado no:Sci Transl Med
Main Authors: Akoumianakis, Ioannis, Badi, Ileana, Douglas, Gillian, Chuaiphichai, Surawee, Herdman, Laura, Akawi, Nadia, Margaritis, Marios, Antonopoulos, Alexios S., Oikonomou, Evangelos K., Psarros, Costas, Galiatsatos, Nikolaos, Tousoulis, Dimitris, Kardos, Attila, Sayeed, Rana, Krasopoulos, George, Petrou, Mario, Schwahn, Uwe, Wohlfart, Paulus, Tennagels, Norbert, Channon, Keith M., Antoniades, Charalambos
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212010/
https://ncbi.nlm.nih.gov/pubmed/32350133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav8824
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