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APOBEC3A loop 1 is a determinant for ssDNA binding and deamination

The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3 or A3) family of proteins functions in the innate immune system. The A3 proteins are interferon inducible and hypermutate deoxycytidine to deoxyuridine in foreign single-stranded DNA (ssDNA). However, this deaminase activ...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Ziegler, Samantha J., Hu, Yingxia, Devarkar, Swapnil C., Xiong, Yong
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211764/
https://ncbi.nlm.nih.gov/pubmed/31448897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00394
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