Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis

This study investigates the role of NLRP3 inflammasome and its main effector Caspase-1 in inflammation and alveolar bone resorption associated with periodontitis. Heat-killed Aggregatibacter actinomycetemcomitans (Aa) was injected 3x/week (4 weeks) into gingival tissues of wild-type (WT), Nlrp3-KO a...

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Publicado en:Sci Rep
Autores principales: Rocha, Fernanda R G., Delitto, Andrea E., de Souza, Joao A. Chaves, González-Maldonado, Laura A., Wallet, Shannon M., Rossa Junior, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210885/
https://ncbi.nlm.nih.gov/pubmed/32385413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64685-y
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