The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

Lineage-specific genetic programs rely on cell-restricted super-enhancers, which are platforms for high-density transcription factor occupation. It is not known whether super-enhancers synergize specifically with their native promoters or provide autonomous and independent regulatory platforms. Here...

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Veröffentlicht in:Exp Mol Med
Hauptverfasser: Zeng, Xianke, Lee, Hye Kyung, Wang, Chaochen, Achikeh, Precious, Liu, Chengyu, Hennighausen, Lothar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210877/
https://ncbi.nlm.nih.gov/pubmed/32321991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-0425-x
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